Webnes is the Guareschi-Thorpe condensation reaction of 1,3-dicarbonyl compounds with cyanoacetamide [25,26], which was used for the synthesis of large number of pyridones [27–29]. Cyclization of cyanoacetamide with 1,3-dicarbonyl compounds belongs to the 3-2 type of condensation that leads to the formation of pyridone ring. WebThorpe–Ziegler reaction. The Thorpe–Ziegler reaction (named after Jocelyn Field Thorpe and Karl Ziegler), or Ziegler method, is the intramolecular modification with a dinitrile as a reactant and a cyclic ketone as the final reaction product after acidic hydrolysis. The reaction is conceptually related to the Dieckmann condensation.
Piperidine Derivatives. XXII. The Condensation of 1-Methyl-4 …
WebMar 15, 2011 · The Dieckman condensation is an acetoacetic ester condensation in which a dicarboxylic ester is cyclized to a beta-ketonic ester through the action of a base. The dicarboxylic ester must have at least one alpha-hydrogen atom and the carbalkoxy groups must be situated that cyclization will result in a 4-membered ring or larger ring. Discovery … WebThe Dieckman condensation is an acetoacetic ester condensation in which a dicarboxylic ester is cyclized to a beta-ketonic ester through the action of a base. The dicarboxylic ester must have at least one alpha-hydrogen atom and the carbalkoxy groups must be situated that cyclization will result in a 4-membered ring or larger ring. 20串铁锂
Guareschi-Thorpe Condensation The Merck Index Online
In 1908 he moved to the University of Sheffield to a full-time research appointment, and in 1913 applied for and was awarded the chair of organic chemistry at Imperial College, a post he was to hold until 1939. The previous incumbent was Thomas Edward Thorpe - although the two were not related, his father was a close friend of T. E. Thorpe and it was the latter who persuaded him to switch from engineering to chemistry in his undergraduate career. Although Ingold’s obituary giv… Web二腈发生的分子内Thorpe反应也称作Thorpe-Ziegler反应（索普-齐格勒反应）。水解产物是α-氰基酮，继续水解得到β-酮酸，脱羧生成环酮。它是卡尔·齐格勒对Thorpe反应的改进， … The Thorpe–Ziegler reaction (named after Jocelyn Field Thorpe and Karl Ziegler), or Ziegler method, is the intramolecular modification with a dinitrile as a reactant and a cyclic ketone as the final reaction product after acidic hydrolysis. The reaction is conceptually related to the Dieckmann condensation. See more The Thorpe reaction is a chemical reaction described as a self-condensation of aliphatic nitriles catalyzed by base to form enamines. The reaction was discovered by Jocelyn Field Thorpe. See more • Thorpe-Ziegler reaction: 4-Phosphorinanone, 1-phenyl- Organic Syntheses, Coll. Vol. 6, p. 932 (1988); Vol. 53, p. 98 (1973) Link See more 20中央政治局委员